Josie Lawrence has been the member of the Comedy Store Players improvisational troupe since 1987 & come to public attention as a regular guest on the Channel 4 improvisational comedy series Whose Line Is It Anyway? on its launch in 1988. She went in stand her have short-transient television series Josie inside 1991, too in Channel Four. Her more television operate includes a comedy series Non using the Bang & Downwardly Roving, & she is remembered for her performances when Maggie Costello in the cricketing comedy drama Outside Edge alongside Timothy Spall and Brenda Blethyn.

Around 1995 Lawrence played Katharine in the Royal Shakespeare Company production of The Taming of the Shrew at Stratford, also appearing within Faust and The Cherry Orchard. She late took all over a lead role of Anna in the stage musical theater The King and I in London's West End, replacing Elaine Paige. Within 2005, she appeared by using Victoria Wood, Julie Walters and Celia Imrie in the cult West End production of Wood's Acorn Antiques: The Musical theater.

Lawrence starred in the 1992 film Enchanted April alongside Joan Plowright, Miranda Richardson and Alfred Molina.

In a Nineties, Lawrence was among the regular cast of a second improvisational comedy programme, The Masterson Inheritance on BBC Radio 4.

The gifted singer, Lawrence's speciality in Whose Line... was her ability to improvise songs on the spot. She has appeared as a guest in panel games including QI and Never Mind the Buzzcocks and in comedies including Absolutely Fabulous, The Comic Strip and Alas Smith & Jones.